Chapter 1
Limits of Conventional Cancer Chemotherapy (pages 1–31)Chapter 2
Pathophysiological and Vascular Characteristics of Solid Tumors in Relation to Drug Delivery (pages 33–64)Chapter 3
Enhanced Permeability and Retention Effect in Relation to Tumor Targeting (pages 65–84)Chapter 4
Pharmacokinetics of Immunoglobulin G and Serum Albumin: Impact of the Neonatal Fc Receptor on Drug Design (pages 85–120)Chapter 5
Development of Cancer-Targeting Ligands and Ligand-Drug Conjugates (pages 121–168)Chapter 6
Antibody-Directed Enzyme Prodrug Therapy (ADEPT) - Basic Principles and its Practice So Far (pages 169–186)Chapter 7
Imaging Techniques in Drug Development and Clinical Practice (pages 187–224)Chapter 8
Magnetic Nanoparticles in Magnetic Resonance Imaging and Drug Delivery (pages 225–245)Chapter 9
Preclinical and Clinical Tumor Imaging with SPECT/CT and PET/CT (pages 247–288)Chapter 10
Empowered Antibodies for Cancer Therapy (pages 289–323)Chapter 11
Mapping Accessible Vascular Targets to Penetrate Organs and Solid Tumors (pages 325–353)Chapter 12
Considerations of Linker Technologies (pages 355–374)Chapter 13
Antibody-Maytansinoid Conjugates: From the Bench to the Clinic (pages 375–394)Chapter 14
Calicheamicin Antibody-Drug Conjugates and Beyond (pages 395–410)Chapter 15
Antibodies for the Delivery of Radionuclides (pages 411–439)Chapter 16
Bispecific Antibodies and Immune Therapy Targeting (pages 441–482)Chapter 17
Design of Polymer-Drug Conjugates (pages 483–512)Chapter 18
Dendritic Polymers in Oncology: Facts, Features, and Applications (pages 513–551)Chapter 19
Site-Specific Prodrug Activation and the Concept of Self-Immolation (pages 553–589)Chapter 20
Ligand-Assisted Vascular Targeting of Polymer Therapeutics (pages 591–625)Chapter 21
Drug Conjugates with Poly(Ethylene Glycol) (pages 627–665)Chapter 22
Thermo-Responsive Polymers (pages 667–700)Chapter 23
Polysaccharide-Based Drug Conjugates for Tumor Targeting (pages 701–746)Chapter 24
Serum Proteins as Drug Carriers of Anticancer Agents (pages 747–803)Chapter 25
Future Trends, Challenges, and Opportunities with Polymer-Based Combination Therapy in Cancer (pages 805–837)Chapter 26
Clinical Experience with Drug-Polymer Conjugates (pages 839–884)Chapter 27
Overview on Nanocarriers as Delivery Systems (pages 885–905)Chapter 28
Development of PEGylated Liposomes (pages 907–949)Chapter 29
Immunoliposomes (pages 951–987)Chapter 30
Responsive Liposomes (for Solid Tumor Therapy) (pages 989–1012)Chapter 31
Nanoscale Delivery Systems for Combination Chemotherapy (pages 1013–1050)Chapter 32
Micellar Structures as Drug Delivery Systems (pages 1051–1069)Chapter 33
Tailor-Made Hydrogels for Tumor Delivery (pages 1071–1097)Chapter 34
pH-Triggered Micelles for Tumor Delivery (pages 1099–1131)Chapter 35
Albumin-Drug Nanoparticles (pages 1133–1161)Chapter 36
Carbon Nanotubes (pages 1163–1185)Chapter 37
Cell-Penetrating Peptides in Cancer Targeting (pages 1187–1217)Chapter 38
Targeting to Peptide Receptors (pages 1219–1261)Chapter 39
Aptamer Conjugates: Emerging Delivery Platforms for Targeted Cancer Therapy (pages 1263–1281)Chapter 40
Design and Synthesis of Drug Conjugates of Vitamins and Growth Factors (pages 1283–1322)Chapter 41
Drug Conjugates with Polyunsaturated Fatty Acids (pages 1323–1357)Chapter 42
RNA Drug Delivery Approaches (pages 1359–1390)Chapter 43
Local Gene Delivery for Therapy of Solid Tumors (pages 1391–1413)Chapter 44
Viral Vectors for RNA Interference Applications in Cancer Research and Therapy (pages 1415–1442)Chapter 45
Design of Targeted Protein Toxins (pages 1443–1487)Chapter 46
Drug Targeting to the Central Nervous System (pages 1489–1517)Chapter 47
Liver Tumor Targeting (pages 1519–1568)Chapter 48
Photodynamic Therapy: Photosensitizer Targeting and Delivery (pages 1569–1603)Chapter 49
Tumor-Targeting Strategies with Anticancer Platinum Complexes (pages 1605–1629)Index (pages 1631–1689)