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| 书名： | Essential Guide to Blood Groups | |
|---|---|---|
| 作者： | Bromilow, Imelda; Geoff, Frcpath Daniels Phd ; Imelda, Cbiol Bromilow ; Daniels, Geoff | |
| 出版时间： | 2010-07-30 | |
| ISBN： | 9781444335309(P-ISBN) ，9781444325195(O-ISBN) | |
| 摘要： | ||
| 摘要： | ||
书目详情：
Essential Guideto Blood GroupsContentsAbbreviationsCHAPTER 1 An introduction to blood groupsWhat is a blood group?Blood group antibodiesClinical importance of blood groupsBiological importance of blood groupsBlood group systemsBlood group terminology and classificationCHAPTER 2 Techniques used in bloodFactors affecting antigen–antibody reactionsTemperatureTime and ionic strengthpHAntigen densityStages of haemagglutination reactionsDirect agglutinationIndirect agglutinationEnzyme techniquesAntiglobulin testsElution techniquesAutomation of test proceduresFlow cytometryMolecular blood group genotypingCHAPTER 3 The ABO blood groupsIntroductionABO antigens, antibodies, and inheritanceA1 and A2Antigen, phenotype, and gene frequenciesABO antibodiesImportance of the ABO system to transfusion andtransplantation medicineBiochemical nature of the ABO antigensBiosynthesis of the ABO antigens and ABOmolecular geneticsH, the precursor of A and BABH secretionH-deficient red cellsFurther complexitiesAcquired changesAssociations with disease and functional aspectsCHAPTER 4 The Rh blood group systemIntroduction – Rh, not rhesusHaplotypes, genotypes, and phenotypesBiochemistry and molecular geneticsD antigen RH1)Molecular basis of the D polymorphismD variantsClinical significance of anti-DD testingC, c, E, and e antigens RH2, RH4, RH3, RH5)Clinical significance of CcEe antibodiesMolecular basis of the C/c and E/e polymorphismsOther Rh antigensCompound antigens: ce, Ce, CE, cE RH6, RH7, RH22, RH27) andG RH12)Cw, Cx, MAR RH8, RH9, RH51)VS, V RH20, RH10)Rh-deficient phenotypes – Rhnull and RhmodPutative function of the Rh proteins and RhAGCHAPTER 5 Other blood groupsThe Kell systemKell glycoprotein and the KEL geneKell system antigensKell system antibodiesKo phenotypeMcLeod syndrome, McLeod phenotype, and Kx XK1) antigenThe Duffy systemFya FY1) and Fyb FY2)Anti-Fya and -FybFy3 and Fy5The Duffy glycoprotein, a receptor for chemokinesDuffy and malariaThe Kidd systemJka JK1) and Jkb JK2); anti-Jka and -JkbJka−b−) and Jk3The Kidd glycoprotein is a urea transporterThe MNS systemM MNS1) and N MNS2); anti-M and -NS MNS3) and s MNS4); anti-S and -sS− s− U− phenotype and anti-UOther MNS antigens and antibodiesThe Diego systemBand 3, the red cell anion exchangerDia DI1) and Dib DI2); anti-Dia and -DibWra DI3) and Wrb DI4); anti-Wra and -WrbOther Diego system antigensThe Lewis systemSome other blood group systemsP1PKLutheranYtXgSciannaDombrockColtonLandsteiner–Wiener LW)Chido/RodgersGerbichCromerKnopsIndianIAntigens that do not belong to a blood group systemCHAPTER 6 Clinical significance of bloodgroup antibodiesAntibody production and structureFactors affecting the clinical significance ofantibodiesAntibody specificityHaemolytic transfusion reactions HTR)Intravascular red cell destructionExtravascular red cell destructionHaemolytic disease of the fetus and newbornHDFN)Cross-matching for infants under 4 months oldAutoantibodiesTests to assess the potential significance ofan antibodyDecision-making for transfusionCHAPTER 7 Blood grouping from DNAFetal blood groupingBlood group typing of patients and donorsCHAPTER 8 Quality assurance inimmunohaematologyAchieving total qualityFrequency and specificity of control materialQuality requirements for safe transfusion practiceChecklist of critical control pointsLaboratory errors, root cause analysis RCA) andcorrective and preventative action CAPA)CHAPTER 9 Trouble-shooting andproblem-solving in thereference laboratoryABO groupingRh groupingProblems in antibody screening, identification, andcross-matchingCHAPTER 10 Frequently asked questionsRecommended readingIndex
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