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书名：	Physics of Living Processes : A Mesoscopic Approach
作者：	Waigh, Thomas Andrew; Waigh, Tom A
出版时间：	2014-08-08
ISBN：	9781118449943(P-ISBN) ，9781118698303(O-ISBN)
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摘要：

书目详情：

The Physics of Living Processes: A Mesoscopic Approach Copyright Contents Preface Acknowledgements Part I: Building Blocks 1 Molecules 1.1 Chemical Bonds and Molecular Interactions 1.2 Chirality 1.3 Proteins 1.4 Lipids 1.5 Nucleic Acids 1.6 Carbohydrates 1.7 Water 1.8 Proteoglycans and Glycoproteins 1.9 Viruses 1.10 Other Molecules Suggested Reading Tutorial Questions 1 2 Cells 2.1 The First Cell 2.2 Metabolism 2.3 Central Dogma of Biology 2.4 Darwin’s Theory of Natural Selection 2.5 Mutations and Cancer 2.6 Prokaryotic Cells 2.7 Eukaryotic Cells 2.8 Chromosomes 2.9 Cell Cycle 2.10 Genetic Code 2.11 Genetic Networks 2.12 Human Genome Project 2.13 Genetic Fingerprinting 2.14 Genetic Engineering 2.15 Tissues 2.16 Cells as Experimental Models 2.17 Stem Cells Suggested Reading Tutorial Questions 2 Part II Soft Condensed-Matter Techniques in Biology 3 Introduction to Statistics in Biology 3.1 Statistics 3.2 Entropy 3.3 Information 3.4 Free Energy 3.5 Partition Function 3.6 Conditional Probability 3.7 Networks Suggested Reading Tutorial Questions 3 4 Mesoscopic Forces 4.1 Cohesive Forces 4.2 Hydrogen Bonding 4.3 Electrostatics 4.3.1 Unscreened Electrostatic Interactions 4.3.2 Screened Electrostatic Interactions 4.3.3 The Force Between Charged Aqueous Spheres 4.4 Steric and Fluctuation Forces 4.5 Depletion Forces 4.6 Hydrodynamic Interactions 4.7 Bell’s Equation 4.8 Direct Experimental Measurements Suggested Reading Tutorial Questions 4 5 Phase Transitions 5.1 The Basics 5.2 Helix–Coil Transition 5.3 Globule–Coil Transition 5.4 Crystallisation 5.5 Liquid–Liquid Demixing Phase Separation)Suggested Reading Tutorial Questions 5 6 Liquid Crystallinity 6.1 The Basics 6.2 Liquid Nematic–Smectic Transitions 6.3 Defects 6.4 More Exotic Possibilities for Liquid-Crystalline Phases Suggested Reading Tutorial Questions 6 7 Motility 7.1 Diffusion 7.2 Low Reynolds Number Dynamics 7.3 Motility of Cells and Micro-Organisms 7.4 First-Passage Problem 7.5 Rate Theories of Chemical Reactions 7.6 Subdiffusion Suggested Reading Tutorial Questions 7 8 Aggregating Self-Assembly 8.1 Surface-Active Molecules Surfactants)8.2 Viruses 8.3 Self-Assembly of Proteins 8.4 Polymerisation of Cytoskeletal Filaments Motility)Suggested Reading Tutorial Questions 8 9 Surface Phenomena 9.1 Surface Tension 9.2 Adhesion 9.3 Wetting 9.4 Capillarity 9.5 Experimental Techniques 9.6 Friction 9.7 Adsorption Kinetics 9.8 Other Physical Surface Phenomena Suggested Reading Tutorial Questions 9 10 Biomacromolecules 10.1 Flexibility of Macromolecules 10.2 Good/Bad Solvents and the Size of Flexible Polymers 10.3 Elasticity 10.4 Damped Motion of Soft Molecules 10.5 Dynamics of Polymer Chains 10.6 Topology of Polymer Chains – Supercoiling Suggested Reading Tutorial Questions 10 11 Charged Ions and Polymers 11.1 Electrostatics 11.2 Deybe–Huckel Theory 11.3 Ionic Radius 11.4 The Behaviour of Polyelectrolytes 11.5 Donnan Equilibria 11.6 Titration Curves 11.7 Poisson–Boltzmann Theory for Cylindrical Charge Distributions 11.8 Charge Condensation 11.9 Other Polyelectrolyte Phenomena Suggested Reading Tutorial Questions 11 12 Membranes 12.1 Undulations 12.2 Bending Resistance 12.3 Elasticity 12.4 Intermembrane Forces 12.5 Passive/Active Transport 12.6 Vesicles Suggested Reading Tutorial Questions 12 13 Continuum Mechanics 13.1 Structural Mechanics 13.2 Composites 13.3 Foams 13.4 Fracture 13.5 Morphology Suggested Reading Tutorial Questions 13 14 Fluid Mechanics 14.1 Newton’s Law of Viscosity 14.2 Navier–Stokes Equations 14.3 Pipe Flow 14.4 Vascular Networks 14.5 Haemodynamics 14.6 Circulatory Systems 14.7 Lungs Suggested Reading Tutorial Questions 14 15 Rheology 15.1 Storage and Loss Moduli 15.2 Rheological Functions 15.3 Examples from Biology: Neutral Polymer Solutions, Polyelectrolytes, Gels, Colloids, Liquid Crystalline Polymers, Glasses, Microfluidics 15.3.1 Neutral Polymer Solutions 15.3.2 Polyelectrolytes 15.3.3 Gels 15.3.4 Colloids 15.3.5 Liquid-Crystalline Polymers 15.3.6 Glassy Materials 15.3.7 Microfluidics in Channels 15.4 Viscoelasticity of the Cell Suggested Reading Tutorial Questions 15 16 Motors 16.1 Self-Assembling Motility – Polymerisation of Actin and Tubulin 16.2 Parallelised Linear Stepper Motors – Striated Muscle 16.3 Rotatory Motors 16.4 Ratchet Models 16.5 Other Systems Suggested Reading Tutorial Questions 16 17 Structural Biomaterials 17.1 Cartilage – Tough Shock Absorbers in Human Joints 17.2 Spider Silk 17.3 Elastin and Resilin 17.4 Bone 17.5 Adhesive Proteins 17.6 Nacre and Mineral Composites Suggested Reading Tutorial Questions 17 18 Phase Behaviour of DNA 18.1 Chromatin – Naturally Packaged DNA Chains 18.2 DNA Compaction – An Example of Polyelectrolyte Complexation 18.3 Facilitated Diffusion Suggested Reading Part III Experimental Techniques 19 Experimental Techniques 19.1 Mass Spectroscopy 19.2 Thermodynamics 19.2.1 Differential Scanning Calorimetry 19.2.2 Isothermal Titration Calorimetry 19.2.3 Surface Plasmon Resonance and Interferometry-Based Biosensors 19.3 Hydrodynamics 19.4 Optical Spectroscopy 19.4.1 Rayleigh Scattering 19.4.2 Brillouin Scattering 19.4.3 Terahertz/Microwave Spectroscopy 19.4.4 Infrared Spectroscopy 19.4.5 Raman Spectroscopy 19.4.6 Nonlinear Spectroscopy 19.4.7 Circular Dichroism and UV Spectroscopy 19.5 Optical Microscopy 19.5.1 Fluorescence Microscopy 19.5.2 Super-Resolution Microscopy 19.5.3 Nonlinear Microscopy 19.5.4 Polarisation Microscopy 19.5.5 Optical Coherence Tomography 19.5.6 Holographic Microscopy 19.5.7 Other Microscopy Techniques 19.6 Single-Molecule Detection 19.7 Single-Molecule Mechanics and Force Measurements 19.8 Electron Microscopy 19.9 Nuclear Magnetic Resonance Spectroscopy 19.10 Static Scattering Techniques 19.11 Dynamic Scattering Techniques 19.12 Osmotic Pressure 19.13 Chromatography 19.14 Electrophoresis 19.15 Sedimentation 19.16 Rheology 19.17 Tribology 19.18 Solid Mechanical Properties Suggested Reading Tutorial Questions 19 Part IV Systems Biology 20 Chemical Kinetics 20.1 Conservation Laws 20.2 Free Energy 20.3 Reaction Rates 20.4 Consecutive Reactions 20.5 Case I and II Reactions 20.6 Parallel Reactions 20.7 Approach to Chemical Equilibrium 20.8 Quasi-Steady-State Approximation 20.9 General Kinetic Equation Analysis Suggested Reading Tutorial Questions 20 21 Enzyme Kinetics 21.1 Michaelis–Menten Kinetics 21.2 Lineweaver–Burke Plot 21.3 Enzyme Inhibition 21.4 Competitive Inhibition 21.5 Allosteric Inhibition 21.6 Cooperativity 21.7 Hill Plot 21.8 Single Enzyme Molecules Suggested Reading Tutorial Questions 21 22 Introduction to Systems Biology 22.1 Integrative Model of the Cell 22.2 Transcription Networks 22.3 Gene Regulation 22.4 Lac Operon 22.5 Repressilator 22.6 Autoregulation 22.7 Network Motifs 22.8 Robustness 22.9 Morphogenesis 22.10 Kinetic Proofreading 22.11 Temporal Programs 22.12 Nonlinear Models 22.13 Population Dynamics Suggested Reading Tutorial Questions 22 Part V Spikes, Brains and the Senses 23 Spikes 23.1 Structure and Function of a Neuron 23.2 Membrane Potential 23.3 Ion Channels 23.4 Voltage Clamps and Patch Clamps 23.5 Nernst Equation 23.6 Electrical Circuit Model of a Cell Membrane 23.7 Cable Equation 23.8 Hodgkin–Huxley Model 23.9 Action Potential 23.10 Spikes – Travelling Electrical Waves 23.11 Cell Signalling Suggested Reading Tutorial Questions 23 24 Physiology of Cells and Organisms 24.1 Feedback Loops 24.2 Nonlinear Behaviour 24.3 Potential Outside an Axon 24.4 Electromechanical Properties of the Heart 24.5 Electrocardiogram 24.6 Electroencephalography Suggested Reading Tutorial Questions 24 25 The Senses 25.1 Biological Senses 25.2 Weber’s Law 25.3 Information Processing and Hyperacuity 25.4 Mechanoreceptors 25.5 Chemoreceptors 25.6 Photoreceptors 25.7 Thermoreceptors 25.8 Electroreceptors 25.9 Magnetoreceptors Suggested Reading Tutorial Questions 25 26 Brains 26.1 Neural Encoding Inverse Problem 26.2 Memory 26.3 Motor Processes 26.4 Connectome 26.5 Cohesive Properties Suggested Reading Tutorial Questions 26 Appendix A Physical Constants Appendix B Answers to Tutorial Questions Index

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