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| 书名： | DNA Vaccines: Types, Advantages and Limitations | |
|---|---|---|
| 作者： | Donnelly, Erin C.; Dixon, Arthur M. | |
| 出版时间： | 2011-11-01 | |
| ISBN： | 9781613244449(P-ISBN) ，9781620810453(O-ISBN) | |
| 摘要： | ||
| 摘要： | ||
书目详情：
DNA VACCINES: TYPES, ADVANTAGES AND LIMITATIONSDNA VACCINES: TYPES, ADVANTAGES AND LIMITATIONSLibrary of Congress Cataloging-in-Publication DataContentsPrefaceChapter I Novel Carrier Adjuvant for DNA VaccinationAbstract1. Introduction2. Immunology of DNA Vaccines: Mode of Action and Immune Response Induction3. Barriers in DNA Vaccine Delivery and Possible Modes to Overcome these Barriers4. Novel Strategies for DNA Delivery4.1. Lipid Based Carrier Adjuvants for DNA Vaccination4.1.1. Liposomes4.1.2. Virosomes4.2. Polymers and Polymeric Carriers Systems4.2.1. Polyethylenimine4.2.2. Polylysine4.2.3. Chitosan4.2.4. Dendrimers4.2.5. Poly Lactide-Co-Glycolide) PLG)5. Concluding Remark and Future ProspectsReferencesChapter II Improving the Immunogenicity of DNA Vaccines: A Nano-Sized Task?AbstractIntroductionImproving Immunogenicity of Plasmid DNA VaccinesRoutes of Delivery of Plasmid DNA VaccinesPhysical Delivery Systems of Plasmid DNA VaccinesNeedle-Free Delivery MethodsExpression OptimizationCytokinesDelivery Vectors for DNA VaccinesBacterial VectorsViral VectorsDNA and RNA RepliconsNano-Sized Vehicles for Gene DeliveryInorganic to Biomaterial – Past to FutureSize Determines the Fate of ParticlesConclusionReferencesChapter III Novel Delivery Strategies for DNAAbstractI. IntroductionII. Optimization of Immunogenicity of DNA Vaccines2.1. Choice of Targets and Expression Plasmid for DNA Vaccines2.2. Selection of High Expression Plasmids for DNA Vaccines2.3. Codon Optimization for Higher Gene Expression2.4. Adjuvant Choice for DNA VaccinesIII. DNA Delivery Strategies3.1. Invasive Delivery3.1.1. Needle Injection3.1.2. In Vivo Electroporation3.1.3. Tattoo Gun Delivery3.2. Non-Invasive Topical Delivery Method3.2.1. Tape Stripping3.2.2. Nanopatch Delivery3.2.3. Nano-Particle Mediated Delivery3.3. Viral-Mediated DNA Delivery Systems3.4. Non-Viral Gene Delivery Systems3.5. Novel Delivery Methods3.5.1. Laser Mediated Delivery3.5.2. Ultrasound Mediated Delivery SystemIII. Future DirectionsReferencesChapter IV Recent Advances in DNA VaccinesAbstractIntroductionDNA Vaccines X Traditional Vaccine ApproachesComponents of a DNA VaccineHow DNA Vaccines WorkDelivery MethodsAdvantages X LimitationsStrategies to Enhance Immunogenicity of DNA VaccinesModifications of Plasmid Basic DesignDelivery MethodsTarget to Dendritic CellsImproved Immunization ProtocolsAdjuvantsConclusionReferencesChapter V Co-Administration of Gamma Interferon Gene with DNA Vaccine Expressing Duck Hepatitis B Virus DHBV) Proteins Enhances Therapeutic Efficacy of DNA-Based Immunization in Chronic Virus CarriersAbstractIntroductionMaterials and MethodsAnimalsDNA ImmunizationAnalysis of Viral DNAAnalysis of Infectivity of Liver Extracts Collected from Resolved DucksHistopathological and Immuno-Histochemical AnalysisStatistical AnalysisResultsDecrease in Viremia following Co-Immunization with Cytokine Expressing PlasmidsEnhancement of DHBV DNA clearance by Co-Immunization with IFN- expressing PlasmidVirological Analysis and Infectivity of Liver Samples Collected from Resolved AnimalsAdverse Effects of TherapyConclusionAcknowledgmentsReferencesChapter VI The Role of DNA-IL-12 Vaccination in Eosinophilic Inflammation: A ReviewAbstractBasic DNA Vaccine ConceptsStrategies for DNA Vaccine AdministrationStructure and Function of Interleukin-12IL-12 TherapyEosinophilia and AsthmaImpact of pcDNA-IL-12 Administration on Eosinophilia and Pulmonary Hyperreactivity in a Murine ModelReferencesChapter VII Cured By DNA-Genetic Immunization in the Therapeutic SectorAbstractIntroductionModulation of the Immune SystemThe Big Four – Cancer, HIV, Hepatitis and TuberculosisCancerHIVHepatitisTuberculosisClinical TrialsSafety Issues, Limitations and DisadvantagesConclusionReferencesChapter VIII DNA Vaccination against HerpesvirusAbstractIntroductionBovine Herpesvirus-1DNA Vaccine against Bovine Herpesvirus-1Route of ImmunizationChemical AdjuvantsAnimal Response FollowingDNA VaccinationReferencesChapter IX DNA Vaccination: Progress and ChallengesAbstractAbbreviationsIntroductionAdvantages of DNA VaccinesLimitations of DNA VaccinesConclusionAcknowledgmentsReferencesIndex
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